Cyclophosphamide health monitoring

Cyclophosphamide (CAS 50-18-0) is an antineoplastic medication used in chemotherapy and immunosuppressive therapy.

It is a synthetic, nitrogen, mustard-type alkylating agent. It is a fine white to off-white crystalline powder that is soluble in water and ethanol.

Workers may be exposed to cyclophosphamide during packaging, formulation, handling or administration of the drug, clean-up and disposal of chemotherapy drug waste, when assisting patients or when handling or cleaning linen.

Workers at risk of exposure include:

• pharmacists
• medical practitioners
• nurses
• cleaners
• veterinarians
• veterinary nurses
• animal handlers

This guide provides information for those registered medical practitioners engaged by a PCBU to carry out or supervise health monitoring for workers. This guidance should be read in conjunction with the following:

• Health monitoring guide for registered medical practitioners
• Health monitoring guides for hazardous chemicals
• Health monitoring guide for workers
• Health monitoring guide for persons conducting business or undertakings (PCBUs)