Cyclophosphamide (CAS 50-18-0) is an antineoplastic medication used in chemotherapy and immunosuppressive therapy.

It is a synthetic, nitrogen, mustard-type alkylating agent. It is a fine white to off-white crystalline powder that is soluble in water and ethanol.

Workers may be exposed to cyclophosphamide during packaging, formulation, handling or administration of the drug, clean-up and disposal of chemotherapy drug waste, when assisting patients or when handling or cleaning linen.

Workers at risk of exposure include:

  • pharmacists
  • medical practitioners
  • nurses
  • cleaners
  • veterinarians
  • veterinary nurses
  • animal handlers

This guide provides information for those registered medical practitioners engaged by a PCBU to carry out or supervise health monitoring for workers. This guidance should be read in conjunction with the following:

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